Anesthesiology - Paper Rankings

Papers ranked by AI-analyzed total score

Rank	Paper Title	Total	Rigor	Innovation	Journal	Clinical
1	Dapagliflozin and Acute Kidney Injury Following Cardiac Surgery: A Randomized Clinical Trial. JAMA • 2026-07-30	91.5	9	9	10	9
2	Cold exposure aggravates vein occlusion through non-shivering thermogenesis-induced thrombocytopoiesis. Cell research • 2026-07-31	91.5	9	10	10	7
3	Inflammatory Phenotypes In Severe Pneumonia: Clinical Evidence To Mouse Models For Precision Therapeutics. American journal of respiratory and critical care medicine • 2026-07-31	90.0	9	9	9	9
4	EGFR orchestrates neutrophil activation and NETosis via CEBPβ-dependent PGLYRP1 induction. Cell death and differentiation • 2026-01-16	88.5	9	9	9	8
5	Autoantibodies cause nociceptive sensitization in a mouse model of degenerative osteoarthritis. Pain • 2025-01-21	88.5	9	9	8	9
6	Ferroptosis inhibition enhances liver and lung graft function. Cell • 2026-05-10	88.5	9	9	10	7
7	TAK-925 (Danavorexton), an Orexin Receptor 2 Agonist, Reduces Opioid-induced Respiratory Depression and Sedation without Affecting Analgesia in Healthy Men. Anesthesiology • 2025-01-13	88.5	9	9	9	8
8	Convergent transcriptomic and connectomic controllers of information integration and its anaesthetic breakdown across mammalian brains. Nature human behaviour • 2026-01-29	88.5	9	10	9	6
9	Once-weekly semaglutide versus placebo in patients with alcohol use disorder and comorbid obesity: a randomised, double-blind, placebo-controlled trial. Lancet (London, England) • 2026-05-05	88.5	9	8	10	9
10	Infusion of young donor plasma components in older patients modifies the immune and inflammatory response to surgical tissue injury: a randomized clinical trial. Journal of translational medicine • 2025-02-15	88.5	9	9	8	9
11	Antibody-secreting cell repertoires hold high-affinity anti-rocuronium specificities that can induce anaphylaxis in vivo. The Journal of allergy and clinical immunology • 2025-02-02	88.5	9	9	8	9
12	Quantifying immune dysregulation in pneumonia and sepsis with a parsimonious machine-learning model: a multicohort analysis across care settings and reanalysis of a hydrocortisone randomised controlled trial. The Lancet. Respiratory medicine • 2026-03-20	88.5	9	9	8	9
13	Effect of high flow nasal cannula oxygenation on incidence of hypoxia during sedated gastrointestinal endoscopy in patients with obesity: multicentre randomised controlled trial. BMJ (Clinical research ed.) • 2025-02-12	88.5	9	8	10	9
14	The cryo-EM structure and physical basis for anesthetic inhibition of the THIK1 K2P channel. Proceedings of the National Academy of Sciences of the United States of America • 2025-04-03	88.5	9	9	8	9
15	Reinforcement learning based automated anesthesia system for gastrointestinal endoscopy with a multicenter randomized trial. NPJ digital medicine • 2026-04-30	88.5	9	9	9	8
16	Cryo-EM structure enabling virtual screening for the discovery of highly potent TRPM3 antagonists with analgesic efficacy. Neuron • 2026-02-26	88.5	9	10	9	6
17	Cerebral venous blood flow regulates intracerebral pressure and brain clearance via meningeal lymphatic vessels. Nature neuroscience • 2026-07-23	88.5	9	9	10	7
18	A preventive care strategy to reduce moderate or severe acute kidney injury after major surgery (BigpAK-2); a multinational, randomised clinical trial. Lancet (London, England) • 2025-11-17	88.5	9	8	10	9
19	Full-spectrum extract from Cannabis sativa DKJ127 for chronic low back pain: a phase 3 randomized placebo-controlled trial. Nature medicine • 2025-09-30	87.0	9	8	10	8
20	Molecular architecture of human dermal sleeping nociceptors. Cell • 2026-02-06	87.0	9	9	10	6
21	Vascular motion in the dorsal root ganglion sensed by Piezo2 in sensory neurons triggers episodic pain. Neuron • 2025-03-29	87.0	9	9	8	8
22	Hypothalamic clock governs circadian pain. Science (New York, N.Y.) • 2026-03-20	87.0	9	9	10	6
23	Protectin DX resolves fracture-induced postoperative pain in mice via neuronal signaling and GPR37-activated macrophage efferocytosis. The Journal of clinical investigation • 2026-01-16	87.0	9	9	9	7
24	Earlier onset of chemotherapy-induced neuropathic pain in females by ICAM-1-mediated accumulation of perivascular macrophages. Science advances • 2025-04-16	87.0	9	9	8	8
25	Holding vs Continuing GLP-1/GIP Agonists Before Upper Endoscopy: The OCULUS Randomized Clinical Trial. JAMA internal medicine • 2026-03-17	87.0	9	8	9	9
26	Personalized Hemodynamic Resuscitation Targeting Capillary Refill Time in Early Septic Shock: The ANDROMEDA-SHOCK-2 Randomized Clinical Trial. JAMA • 2025-10-29	87.0	9	8	10	8
27	Arrestin-biased allosteric modulator of neurotensin receptor 1 alleviates acute and chronic pain. Cell • 2025-05-21	87.0	9	9	10	6
28	Activation of Spinal Astrocyte α2A Adrenoceptors Protects Against Sepsis-Induced Heart Injury Through Inhibition of GABAergic Neuronal Necroptosis. Advanced science (Weinheim, Baden-Wurttemberg, Germany) • 2025-07-22	87.0	9	9	9	7
29	Synchronicity of pyramidal neurones in the neocortex dominates isoflurane-induced burst suppression in mice. British journal of anaesthesia • 2025-02-01	87.0	9	9	8	8
30	A propofol binding site in the voltage sensor domain mediates inhibition of HCN1 channel activity. Science advances • 2025-01-03	87.0	9	9	8	8
31	TLR4 maintains Treg-mediated protection against adverse outcomes in a model of hepatic surgical stress. The Journal of clinical investigation • 2026-03-03	87.0	9	9	9	7
32	Identifying biomarker-driven subphenotypes of cardiogenic shock: analysis of prospective cohorts and randomized controlled trials. EClinicalMedicine • 2025-01-13	86.0	8	9	9	9
33	Conventional vs Video-Assisted Laryngoscopy for Perioperative Endotracheal Intubations: A Randomized Clinical Trial. JAMA network open • 2026-08-03	85.5	9	8	8	9
34	Elucidation of a potent pro-resolving mediator of inflammation resolution via human neutrophil-vascular endothelial cell interactions. Proceedings of the National Academy of Sciences of the United States of America • 2026-03-20	85.5	9	9	9	6
35	Non-drug perioperative interventions to reduce postoperative pulmonary complications after abdominal surgery: systematic review and meta-analysis. BMJ (Clinical research ed.) • 2026-04-10	85.5	9	7	10	9
36	HIgh versus STAndard blood Pressure target in hypertensive high-risk patients undergoing elective major abdominal surgery: the HISTAP multicenter randomized clinical trial. Intensive care medicine • 2026-06-29	85.5	9	8	8	9
37	General Anesthesia-activated Neurons in the Central Amygdala Mediate Antinociception: Distinct Roles in Acute versus Chronic Phases of Nerve Injury. Anesthesiology • 2025-05-07	85.5	9	9	8	7
38	Non-equilibrium snapshots of ligand efficacy at the μ-opioid receptor. Nature • 2025-12-23	85.5	9	9	10	5
39	Effects of Sedative Doses of Propofol, Dexmedetomidine, and Fentanyl on Memory and Pain in Healthy Young Adults: A Randomized, Controlled, Single-blind Crossover Study Using Functional Magnetic Resonance Imaging at 7 Tesla. Anesthesiology • 2025-04-09	85.5	9	9	7	8
40	Standard-dose unfractionated heparin versus low-dose unfractionated heparin and low-molecular-weight heparin in extracorporeal life support (RATE): an open-label, randomised, non-inferiority trial. Lancet (London, England) • 2026-07-08	85.5	9	7	10	9
41	Sepsis-induced hypocholesterolemia is linked to low cardiomyocyte membrane cholesterol and impaired catecholamine responsiveness. Critical care (London, England) • 2025-09-26	85.5	9	9	8	7
42	Structural basis of opioid receptor activation by PCP and ketamine. Nature structural & molecular biology • 2026-06-23	85.5	9	9	9	6
43	Multimodal Prehabilitation for Older Adults Undergoing Spinal Fusion : A Randomized Clinical Trial. Annals of internal medicine • 2026-06-15	85.5	9	7	10	9
44	NH600001, an etomidate analogue, provides gastrointestinal endoscopy sedation/anesthesia and reduces adrenocortical depression: two randomized controlled trials. Nature communications • 2026-05-06	85.5	9	8	9	8
45	Mitochondrial flagella-like extensions (MitoFLARE) dysfunction triggers STING-mediated immune dysregulation in sepsis. Nature communications • 2026-05-26	85.5	9	9	9	6
46	Ketamine-induced Sustained Modulation of γ-Aminobutyric Acid Type A Receptor Function in Mouse Hippocampal Neurons after Anesthesia. Anesthesiology • 2025-06-09	85.5	9	9	8	7
47	Early repetitive transcranial magnetic stimulation for preventing chronic postoperative pain in older adults: a randomized clinical sub-study. BMC medicine • 2026-04-07	85.5	9	9	7	8
48	Striatal neurones expressing D1 dopamine receptors modulate consciousness in sevoflurane but not propofol anaesthesia in mice. British journal of anaesthesia • 2025-02-07	85.5	9	9	7	8
49	Sensory neuron BRAF mediates opioid-induced hyperalgesia and tolerance via presynaptic NMDA receptor hyperactivity. The Journal of clinical investigation • 2026-07-14	85.5	9	9	8	7
50	RIPK1 Drives JAK1-STAT3 Signaling to Promote CXCL1-Mediated Neutrophil Recruitment in Sepsis-Induced Lung Injury. Advanced science (Weinheim, Baden-Wurttemberg, Germany) • 2025-09-15	85.5	9	9	8	7

About Scores

Rigor (0-10, weight 0.40)

Robustness of research methodology

Innovation (0-10, weight 0.30)

Degree of novel approaches or discoveries

Journal (0-10, weight 0.15)

Journal standing (down-weighted per DORA)

Clinical (0-10, weight 0.15)

Potential impact on clinical practice